Conventional and Microwave-Assisted Synthesis of Fibric Acid based 1,3,4-Oxadiazol Derivatives and Evaluation of their in vivo Anti-hyperglycemic Activity

Authors

  • Majda Batool Department of chemistry, Government Graduate College Township, Lahore
  • Munawar Ali Munawar Department of Chemistry, Faculty of Science, University of Central Punjab, Lahore, Pakistan
  • Muhammad Asim Raza Basra School of Chemistry, University of the Punjab, New Campus, Lahore, Pakistan
  • Sumra Amanat Department of chemistry, Government Graduate College Township, Lahore
  • Shazia Amir Department of chemistry, Government Graduate College Township, Lahore
  • Hafiz Adnan Ahmad Department of chemistry, Government Graduate College Township, Lahore

Abstract

Microwave assisted synthesis, a green synthetic method was applied to synthesize a series of oxadiazole based fibric acid derivatives (3a–h) resulted good to excellent yields (82-96 %) and less reaction time in comparison to conventional methods and ultrasonic methods. The synthesized compounds were characterized by H1 NMR, EI/MS and C13 NMR and their postulated structures were in agreement with spectral data. In present study title compounds were evaluated for their hypoglycemic potential and among them compounds 3c showed the significant biological response. The hypoglycemic effect was compared with glibenclamide.

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Published

27-12-2023

How to Cite

Batool, M., Munawar, M. A., Basra, M. A. R., Amanat, S., Amir, S., & Ahmad, H. A. (2023). Conventional and Microwave-Assisted Synthesis of Fibric Acid based 1,3,4-Oxadiazol Derivatives and Evaluation of their in vivo Anti-hyperglycemic Activity . Research Prospects in Natural Sciences (RPNS), 1(1), 1–5. Retrieved from https://journals.gctownship.edu.pk/index.php/rpns/article/view/65

Issue

Vol. 1 No. 1 (2023): Research Prospects in Natural Sciences

Section

Chemistry