Synthesis and antibacterial activity of synthesized derivative of sulphonamide drug of 1,3-thiazole

Abstract

The amalgamation of two heterocyclic moieties i.e. 1,3-thiazole and 1,3,4-oxadiazole, were carried out in the designed molecules to impart them possible therapeutic properties. The new compounds have been synthesized by encompassing different bioactive moieties including 1,3-thiazole, sulphonyl, alkyl halid. The synthesized molecules have been subjected to evaluation of their antibacterial potential. Furthermore, enzyme inhibition potential results have been supported by computational docking in order to find the types of interactions with the active site of involved enzymes.